SERPINF1 and myalgic encephalomeyelitis/chronic fatigue syndrome: Seven proteins exhibited significantly different 15 min/0 h ratios between ME/CFS patients and controls, with five being downregulated in ME/CFS (CS, MAGED2, NSF, SNCA, and TKT) and two being upregulated (GP1BA and SERPINF1) (Figure 4A, q < .1).