In our previous study on female EV proteomics postexercise, we observed that EMILIN1 levels were significantly higher in ME/CFS patients compared with healthy controls 24 h after exercise,28 suggesting that in ME/CFS patients, the elevated EMILIN1 may reflect a more prolonged vascular response to exercise‐related stress, which may contribute to patients’ exercise intolerance. The gene discussed is EMILIN1; the disease is myalgic encephalomeyelitis/chronic fatigue syndrome.