The Somogyi effect, a hypothesis proposed by Michael Somogyi in 1938 [11, 12], suggests that insulin-induced nocturnal hypoglycemia might stimulate the secretion of counterregulatory hormones [13, 14] or induce eating [15], resulting in rebound nocturnal hyperglycemia that the patient with diabetes would often detect at dawn, upon awakening [12]. Here, INS is linked to Hypoglycemia.