There is also a meta-analysis of diagnostic accuracy, which supported that FGF-21 provided a pooled sensitivity of 0.62 (95% CI 0.50–0.73) and specificity of 0.78 (0.70–0.84) for diagnosing NASH, based on the results of four studies [66]. Here, FGF21 is linked to metabolic dysfunction-associated steatohepatitis.