FGF21 and metabolic dysfunction-associated steatohepatitis: The clarification of FGF-21 levels when the disease advances seems to be important in the light of FGF-21 analogs that are currently under investigation in patients with NASH; higher FGF-21 levels may target to limit the progression of the disease, but may also indicate a state of FGF-21 resistance or insensitivity, which may complicate the effect of FGF-21 analogs [8].