However, we could not recommend the use of FGF-21 as a non-invasive index of NASH, based on the results of this [66] or our meta-analysis; of course, our results warrant more diagnostic accuracy studies to clarify whether FGF-21 may add value in the non-invasive diagnosis of NASH or related fibrosis, alone or, more possibly, in combination with other parameters. Here, FGF21 is linked to metabolic dysfunction-associated steatohepatitis.