“Pathological T stage (≥ 3)”, “ISUP grade group of the entire tumor”, “ISUP grade group at SM (≥ 5)”, “Maximum length of cancer at SM (≥ 4 mm)”, “Nadir level of PSA after surgery (nadir-PSA)”, and “Indication of cauterization at SM” were identified as significant factors in the univariate analysis. The gene discussed is KLK3; the disease is cancer.