As a result, the concurrent downregulation of p53, Bcl-2 and ND3 gene expression disrupts mitochondrial stability at multiple levels by weakening membrane integrity, impairing bioenergetic function and genomic maintenance, thereby promoting robust mitochondrial-mediated apoptosis in CaTiO3NPs-treated HNO-97 cancer cells. This evidence concerns the gene MT-ND3 and cancer.