Specifically, we infected HDAC1-cKO and WT mice with the clone 13 strain of LCMV (LCMV Cl13) (Fig. 1 A), which results in chronic viral infection accompanied by a temporal weight loss and hepatitis driven by CD8+ T cells (Baazim et al., 2019; Bergthaler et al., 2007; Doherty et al., 1993; Moskophidis et al., 1993; Zinkernagel et al., 1986). This evidence concerns the gene CD8A and Hepatitis.