Indirectly, this notion is supported by our prior studies showing high blood vessel density in RDEB-affected skin [4] and the data showing elevated concentrations of several pro-inflammatory cytokines including IL-1β (~ 37 pg/ml), IL-6 (~ 40 pg/ml), IL-10 (~ 30 pg/ml), and CXCL8 (~ 50 pg/ml) in the blood of RDEB patients [27]. This evidence concerns the gene CXCL8 and recessive dystrophic epidermolysis bullosa.