In contrast, genes enriched at pHi 7.4 include CDC42EP3, which we also find to be selectively enriched in NHE1-KO cells with ChIP-seq (Fig. 7D), DYNC1H1, and INSYN2, which are not known tumor promoting genes, as well as EP400, CRYBG3, and TRPV2, which promote tumor suppression, cell-cycle arrest, senescence, DNA-damage response, and apoptosis (Fig. 8D) [90–97]. The gene discussed is CRYBG3; the disease is neoplasm.