To further determine the role played by circTP53 in the diverse states of p53 in tumors, we introduced pan‐cancer cell lines (MDA‐MB‐231, A549, H1299, HCT116 p53−/−, HCT116 p53+/+ and Hela) (Figure 8B, Supporting Information) and assessed their epigenetic effects in tumors after knocking down and restoring circTP53. This evidence concerns the gene TP53 and cancer.