As reported, in lung cancer and breast cancer, USP10, an upstream deubiquitinase of p53, prevents the targeted proteasomal degradation of p53 by removing its polyubiquitination.[23, 27] To verify the interaction between USP10 and p53 in HNSCC, Co‐IP assays were conducted in FaDu cells, revealing the coimmunoprecipitation of USP10 and p53 (Supplementary Figure S7A). This evidence concerns the gene USP10 and head and neck squamous cell carcinoma.