The TP53 gene, located on the short arm of chromosome 17, encoding the p53 protein, is the most commonly mutated gene in human cancers including HNSCC.[16] As p53 orchestrates diverse cellular processes such as cell cycle arrest, DNA repair, and apoptosis, p53 is frequently regarded as the “guardian of the genome”. The gene discussed is TP53; the disease is head and neck squamous cell carcinoma.