As a crucial tumor suppressor, wtp53 exerts anti‐cancer effects, whereas most mutant forms of p53 promote tumor progression through other mechanisms, such as gain of function (GOF), loss of function (LOF), dominant negative effect (DNE).[29, 30] Consequently, circTP53 and USP10 may exert dual regulatory effects on tumor progression in HNSCC. Here, USP10 is linked to head and neck squamous cell carcinoma.