USP10 and breast cancer: As reported, in lung cancer and breast cancer, USP10, an upstream deubiquitinase of p53, prevents the targeted proteasomal degradation of p53 by removing its polyubiquitination.[23, 27] To verify the interaction between USP10 and p53 in HNSCC, Co‐IP assays were conducted in FaDu cells, revealing the coimmunoprecipitation of USP10 and p53 (Supplementary Figure S7A).