Recent studies have shown that Ube2k binds to histone H3, induces its ubiquitination, and regulates neural stem cell differentiation and proliferation through proteasome‐mediated degradation of histone H3.[28] Additionally, Ube2k promotes the proliferation and migration of hepatocellular carcinoma cells by upregulating c‐Myc, while knockdown of Ube2k significantly inhibits the malignancy of liver cancer.[29] These findings highlight Ube2k's critical regulatory role in cell differentiation and proliferation. Here, UBE2K is linked to liver cancer.