CD274 and neoplasm: The functional role of HLA‐DR+ tumor cells in the immunosuppressive environment is multifaceted.[25] By presenting tumor antigens, these cells might paradoxically impair effective anti‐tumor immunity by inducing T‐cell exhaustion.[26] Elevated PD‐L1 expression on HLA‐DR+ cells suggests that these cells actively engage immune checkpoints to suppress cytotoxic T‐cell activity.[27] Moreover, the recruitment of CD8+ T cells by HLA‐DR+ tumor cells, followed by their subsequent exhaustion, highlights a potential mechanism by which these cells contribute to immune evasion.