H3K4me3 instead of H3K27me3 peaks were shown more enrichment at SLC7A11 promoter regions in MCF10A cells (Figure 6—figure supplement 7A and B), while 5-mC levels at CpG islands among SLC7A11 promoter regions were also increased in MCF10A (Figure 6—figure supplement 7C), revealing the important proposal of histone modifications and DNA methylation on metabolic reprogramming during the evolution of HER2-positive breast cancer. The gene discussed is SLC7A11; the disease is breast carcinoma.