GLI2 and otofaciocervical syndrome 1: Genetic interactions between risk alleles play a pivotal role in OFC pathogenesis, influencing both syndromic and non‐syndromic forms.[24] In Family 4, we identified a novel epistatic interaction between two functionally antagonistic variants: a hypomorphic BOC variant (p.R681X) and a hypermorphic GLI2 variant (p.A543G).