GLI2 and cleft lip: Taken together, these results indicate that GLI2 p.A543G variant acts as a gain‐of‐function mutation both in vivo and in vitro and illustrate a model of two‐locus transmission of cleft lip in a hereditary family, whereby a hypermorphic mutation in GLI2 counteracts a hypomorphic mutation in BOC, giving rise to the unexpected microform cleft lip phenotype.