CYP4F3 and Cowden disease: The interaction between 15 SNPs across 3 PUFA metabolic genes (FADS1, FADS2, and CYP4F3) and dietary ω6 PUFA, ω3 PUFA, and the ω6/ω3 PUFA ratio conferring susceptibility to CD has been explored in pediatric patients.48 No interaction between these 15 SNPs and ω6 intake was detected, but a significant interaction was observed between FADS2 (rs11230815) and dietary ω3 intake in relation to pediatric CD risk (Pinteraction =.042).