No statistically significant interactions between high intake of dietary fats and TNFα-857 or IL6-174 genotypes were found in relation to CD disease activity.46 Nevertheless, a significant risk effect of high intake of saturated and monounsaturated fat as well as the ratio of ω6/ω3 polyunsaturated fatty acid (PUFA) on CD disease activity was observed mainly in subjects with TNFα-857 CT/TT genotype. This evidence concerns the gene IL6 and Cowden disease.