In UC patients, the interaction between CHRNA5 (rs16969968) and smoking status was significantly associated with the risk of IBD-related surgery. (OR = 2.72, 80%CI. 1.42-5.32; P =.05)In CD patients, the interaction between CHRNA5 (rs16969968) and current smoking regarding the risk of IBD-related surgery reached predefined significance level (OR = 2.88, 80%CI, 1.30-6.64, P =.1) Here, CHRNA5 is linked to inflammatory bowel disease.