Given that ER‐stress on loss of functional SIL1 is associated with activation of PERK (a modulator of ER‐stress) in degenerating neurons and PERK‐inhibition has protective effects on protein‐misfolding in models of neurodegenerative disease, modulation of PERK‐activation by GSK2606414 (a selective PERK‐inhibitor) was tested.135. This evidence concerns the gene EIF2AK3 and neurodegenerative disease.