Registry‐inventoried natural history cohorts of genetically stratified ARCA patients have been built up for ARCAs in general (eg, ARCA Registry),140 and for specific ARCAs such as FRDA (European Friedrich's Ataxia Consortium for Translational Studies [EFACTS]),141 COQ8A (preparing therapies for autosomal recessive ataxias [PREPARE]), RFC1 (RFC1 Natural History Study, NCT05177809) or SPG7 and ARSACS (PROSPAX; NCT04297891). This evidence concerns the gene RFC1 and cerebellar ataxia.