They demonstrated that over 17‐fold enhancement of binding affinity by 5‐quinoline modification in Apc001OA‐d6 and 5‐quinoline modification could facilitate the modified aptamer attenuating the suppressed effect of the transfected sclerostin on both Wnt signalling in vitro, which was almost the same level of romosozumab in OI mice [20]. This evidence concerns the gene SOST and osteogenesis imperfecta.