Recent studies have demonstrated that the activation of Dkk3 exacerbates age‐related muscle atrophy by promoting the recruitment of β‐catenin to the binding sites of Forkhead box O3 (FoxO3), a member of the Fox family of transcription factors, located in the promoter regions of genes encoding Fbxo32 and Murf1 [8]. The gene discussed is DKK3; the disease is Atrophy.