FGF23 and hyperphosphatemia: demonstrated that targeted ablation of Fgf23 resulted in skeletal muscle atrophy in homozygous mice, raising the possibility that FGF23 might affect skeletal muscle development and myogenesis in vivo [19], although the observed phenotype could potentially have been confounded by concurrent hyperphosphataemia, which can itself induce cellular senescence and reduce myoblast proliferation [34].