Peritonitis (OR = 95.635, 95% CI: 25.312\u2013361.339), IL-6 (OR = 1.001, 95% CI: 1.000\u20131.001), and portal venous gas (OR = 22.551, 95% CI: 1.802\u2013282.190) were identified as independent factors for predicting early surgical indications in NEC (P < 0.05) see Table 7. The gene discussed is IL6; the disease is necrotizing enterocolitis.