ANGPTL3 and hyperlipidemia: Angiopoietin-like 3 (ANGPTL3) represents a compelling target for hyperlipidaemia, as studies indicate that loss-of-function variants are associated with markedly reduced LDL-cholesterol and triglyceride levels, along with a diminished risk of coronary heart disease (CHD) (Sosnowska et al., 2022).