PARK7 and Parkinson disease: The role of Drp1 has been identified as a contributing factor in the pathogenesis of Parkinson’s disease (Wu et al., 2017), with a substantial body of evidence demonstrating the involvement of α-Syn, DJ-1, LRRK2, PINK1, and Parkin in the regulation of mitochondrial dynamics and homeostasis through the Drp1 pathway (Irrcher et al., 2010; Kamp et al., 2010).