NFKB1 and Alzheimer disease: Furthermore, PGC-1α suppresses the transport of NF-κB p65 from the cytoplasm to the nucleus and the degradation of IκBα by regulating NF-κB, thereby reducing Aβ-induced neuronal death and inhibiting neuroinflammation, which in turn reduces mitochondrial damage and restores AD cognitive deficits (Zhang Y. et al., 2017).