MAPT and early-onset autosomal dominant Alzheimer disease: The pathological features of Alzheimer’s disease include the abnormal deposition and accumulation of β-amyloid (Aβ) and phosphorylated tau (p-tau) in neurons, which induce neurogenic fiber tangles, leading to impaired synaptic and cholinergic neuronal function (Ashleigh et al., 2023; Pritam et al., 2022).