Studies have reported that more than 210 gene mutations contribute to the progression of ALS, with mutations in superoxide dismutase 1 (SOD1), fusion sarcoma gene (FUS), TAR DNA binding protein 43 (TDP-43), and other genes being recognized as risk factors for the development of ALS (Alami et al., 2014). The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.