Thus, tauopathies, which are characterized by the formation of tau deposits, have been observed in TBI (Alyenbaawi et al., 2021), ischemic stroke (Hayden et al., 2019), Alzheimer’s disease (Congdon et al., 2022), Parkinson’s disease (Meloni et al., 2023), Huntington’s disease (Baskota et al., 2019), ALS (Montalbano et al., 2020) and many other disorders. The gene discussed is MAPT; the disease is early-onset autosomal dominant Alzheimer disease.