ACE and obesity due to melanocortin 4 receptor deficiency: Significantly more patients with obesity in the infertile group took metformin, β-blocker, α2 adrenergic receptor agonist, acetylsalicylic acid, and levothyroxine but there was no significant difference between the two groups with respect to the usage of angiotensin-converting enzyme inhibitors, or angiotensin receptor blockers, Ca2+-channel blockers, imidazolidine or α2 adrenergic receptor agonists, statins, and diuretics (Table 1).