MYLK2 and prostate adenocarcinoma: We demonstrated the distribution of differences between ITH-score levels and T-levels, N-levels, M-levels, gleason scores, and age in PRAD patients (Supplementary Figures S2A–E), and more comprehensively showed significant correlations between the elite gene MYLK2 and fustat indicators and all the clinical information mentioned above, as well as the ITH-score, in PRAD patients by heatmaps (Supplementary Figure S2F).