CYP3A5 and hypertensive disorder: Conversely, other studies found the CYP3A5*3 allele to be associated with higher blood pressure (Galaviz-Hernández et al., 2020; Fromm et al., 2005; Ho et al., 2005; Kreutz et al., 2005; Zhang et al., 2010) and increased HTN risk (Galaviz-Hernández et al., 2020).