CYP3A5 and hypertensive disorder: Considering that our primary results did not show any associations between CYP3A5 variants or CYP3A5 activity and blood pressure-related phenotypes and given that the significant findings in the subgroups are restricted to the White population, this suggests the presence of other factors influencing blood pressure and HTN, which may account for the differences observed between White participants and other ancestral populations, as well as the lack of findings within the whole population.