TERT and glioblastoma: Another slight limitation of existing TERT inhibitors is that they require multiple cell divisions before cell death.8 However, epidermal growth factor receptor (EGFR) amplification and TERT promoter mutations commonly occur together in GBM,12 and recent studies have shown that EGFR signaling can further regulate TERT expression by regulating the expression of GABP.12 These studies have also shown that targeting the EGFR pathway has the potential to enhance the effectiveness of TERT inhibition.