Patients who died also were older, had higher incidence of peripheral vascular disease, dementia, and chronic pulmonary disease, and had elevated levels of HR, RR, WBC, INR, PT, creatinine, BUN, ALT, AST, ALP, CKMB, BNP, K+, Na+, Ca2+, Cl−, anion gap, glucose, and lactate. This evidence concerns the gene NPPB and peripheral vascular disease.