DSG4 and lipodystrophy: Although the sample size is limited, we also recovered ClinVar-annotated pathogenic variants in the QHA and QMO WGS subsets that are more frequent than in the matched gnomAD populations, such as a variant in AGPAT2 (causing lipodystrophy) previously found in families of African descent, and variants in FAM161A (causing retinitis pigmentosa) and DSG4 (causing hypotrichosis) previously identified in Moroccan Jewish families (Supplementary Table 4).