Hypogonadotropic hypogonadism (HH) usually results from an insufficient secretion of gonadotropin-releasing hormone (GnRH) from the mediobasal hypothalamus, resulting in deficiency of gonadotropin secretion (LH and FSH), by the anterior pituitary gland, and consequently decreased endogenous sex steroid production by the gonads (Dodé and Hardelin, 2009; Argente et al., 2023). This evidence concerns the gene PLOD1 and hypogonadotropic hypogonadism.