A phosphorylated dendrimer polymer/anti-PD-1 nano-delivery system encapsulated with Mlm has also been developed, which demonstrates the capacity to penetrate the blood–brain barrier and enhances the immunotherapeutic efficacy against gliomas by synergistically regulating NK cell and T cell functions, offering novel approaches for the development of tumor immunotherapy strategies [68]. This evidence concerns the gene PDCD1 and neoplasm.