In addition to reducing blood volume, which directly alleviates hemodynamic congestion and cardiac workload, targeting weight loss could reduce epicardial adipose tissue, relieving pericardial restraint, systemic inflammation, insulin resistance, hormonal activation, adipokines including leptin, dyslipidaemia, and other obesity‐related factors that may contribute to impaired cardiac structure and function [24, 25, 26, 27, 28]. This evidence concerns the gene LEP and obesity due to melanocortin 4 receptor deficiency.