In addition to reducing blood volume, which directly alleviates hemodynamic congestion and cardiac workload, targeting weight loss could reduce epicardial adipose tissue, relieving pericardial restraint, systemic inflammation, insulin resistance, hormonal activation, adipokines including leptin, dyslipidaemia, and other obesity‐related factors that may contribute to impaired cardiac structure and function [24, 25, 26, 27, 28]. The gene discussed is INS; the disease is obesity disorder.