Current conventional biomarkers used clinically for the diagnosis and evaluation of sepsis include procalcitoninogen (PCT), C-reactive protein (CRP), white blood cell count (WBC), and a variety of inflammatory cytokines (15–17).However, these conventional markers are often abnormally expressed in the presence of trauma, surgery, and non-infectious diseases, resulting in insufficient specificity and limited sensitivity in distinguishing sepsis from non-infectious inflammation, these traditional markers. The gene discussed is CRP; the disease is infectious disease.