• CS exposure dose dependently increased arthritis score and incidence• CS exposure dose dependently increased inflammation score of joint• CS exposure dose dependently increased destruction score of joint (cellular infiltration, pannus formation, cartilage damage)• CS exposure dose dependently increased citrullinated proteins in tarsal joints (vimentin)• CS exposure increased citrullination in trachea and bronchioles• CS exposure enhanced citrullinated vimentin, enolase, and filaggrin in serum.• CS exposure enhanced ACPA/a-CCP. This evidence concerns the gene FLG and arthritic joint disease.