Therefore, we then compared some of the major inflammatory pathways of AAA and found that the TNF and TGFb signaling pathways are mainly sent by macrophages and received by fibroblasts, while the CCL, ANGPTL, COMPLEMENT, and CXCL signaling pathways are mainly sent by fibroblasts and received by macrophages (Supplementary Figure S3C). The gene discussed is TNF; the disease is triple-A syndrome.