In addition to neurodegenerative diseases and cardiovascular diseases, the cGAS/STING/NLRP3 signaling pathway is involved in the pathological process of acute pancreatitis (36), mastitis (37), acute kidney injury (38), acute liver injury (39), acute lung injury (40), systemic lupus erythematosus (41), and allergic rhinitis (42). This evidence concerns the gene CGAS and neurodegenerative disease.