For instance, lysine acetyltransferase 2A (KAT2A)-mediated histone H3 lysine 79 (H3K79) succinylation upregulates the expression of tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta (YWHAZ), which encodes 14-3-3ζ, thereby enhancing the migratory and invasive capabilities of tumor cells (8). This evidence concerns the gene KAT2A and neoplasm.