MOG and transverse myelitis: Clinical observations reveal that the degree of disability, cerebrospinal fluid (CSF) leukocyte count, and protein levels in MOGAD patients correlate with CSF MOG-IgG titers, but not significantly with serum MOG-IgG titers (81) Furthermore, studies indicate that patients with MOG-IgG ITS tend to exhibit more severe clinical courses, characterized by more pronounced pyramidal tract involvement and spinal cord lesions, with longitudinally extensive transverse myelitis being particularly prominent (83).