SLC16A2 and Allan-Herndon-Dudley syndrome: To understand the mechanistic basis of how maternal hypothyroxinemia (low T4 levels) affects early cerebral cortex development (7), we prepared 50-day-old (D50) COs using MCT8-deficient iPSC prepared with cells from a 6-year-old boy with the Allan-Herndon-Dudley Syndrome (carrying the missense mutation P321L).