Molecular profiling of isolated leukemia cells confirmed expression of lymphoid (rag1 and rag2) and T-cell specific (lck and tcrβ-C2) markers, with no significant upregulation of B-cell genes (pax5, igD-VH1, and igM-VH1), indicating that PRL-3 did not alter leukemia lineage identity (Supplemental Figure 5A). This evidence concerns the gene RAG1 and leukemia.