We found both PRL-3 WT and the phosphatase-dead C104D mutant significantly increased leukemia penetrance compared to mCherry controls (18.2% and 21.6% vs. 8.9%; p ≤ 0.044), whereas the CNNM-binding deficient R138E mutant had no effect (p=0.997; Figure 3A–B). This evidence concerns the gene PTP4A3 and leukemia.