SPTLC1 and type 2 diabetes mellitus: SPTLC2 expression tended to be lowered in islets from patients with T2D compared to non-diabetic controls (padj 0.053 and log2FC −0.27) and SPTLC1 expression was significantly reduced (padj 3.5E-0.3 and log2FC −0.42) (Figure 6 M, N).