SPTLC1 and type 2 diabetes mellitus: Suggesting that the present data in mice may be relevant for human T2D, variants in the SPTLC1 locus, encoding the non-redundant SPT1 subunit of the complex, are moderately (HuGE score 8.4, 3.0 respectively) [41, 42] associated with HOMA-B and with fasting insulin, with weaker associations in this region for T2D.