The prevailing model for NDRG1’s role in CMT4D suggests that defects in Schwann cells (the myelinating cells of the peripheral nervous system) are driven by NDRG1’s impaired ability to traffic the low-density lipoprotein receptor (LDLR), thus resulting in impaired intake of cholesterol which constitutes a significant component of lipid-rich myelin (Pietiäinen et al., 2013). Here, LDLR is linked to Charcot-Marie-Tooth disease type 4D.