NDRG1 and Charcot-Marie-Tooth disease type 4D: Charcot-Marie-Tooth Disease Type 4D (CMT4D), which has been linked to mutations in NDRG1, is characterized by demyelination of motor and sensory nerves leading to muscle weakness, atrophy, and sensory loss, typically beginning in the distal limbs (Echaniz-Laguna et al., 2007).