These results carry significant implications for understanding the pathology of Charcot-Marie-Tooth Disease Type 4D, a sensorimotor neuropathy which has been linked to mutations in NDRG1 and is characterized by peripheral nerve demyelination and muscle atrophy (Echaniz-Laguna et al., 2007). The gene discussed is NDRG1; the disease is Charcot-Marie-Tooth disease type 4D.