Any disruption to the unidirectional flow of Rho into the OS causes Rho mislocalization, which is the typical subcellular outcome of blinding rod diseases caused either by a genetic variant (Guo et al., 2022; Hagstrom et al., 1999) or retinal detachment (Fariss et al., 1997; Fisher et al., 2005). The gene discussed is RHO; the disease is retinal detachment.