Rho mislocalization in the OPL has also been demonstrated in RP dog and human retinas (Beltran et al., 2006; Fariss et al., 2000; Milam et al., 1998), as well as after retinal detachment (Fariss et al., 1997; Fisher et al., 2005); however, the impact of Rho OPL mislocalization on rod spherule structure and synaptic protein trafficking and turnover has never been investigated. Here, RHO is linked to retinal detachment.