CD40LG and myeloid sarcoma: 2022), this single‐tissue approach potentially overlooks contributions from peripheral inflammatory mediators. Future studies should incorporate multi‐tissue expression databases (e.g., GTEx) to systematically evaluate CD40/CD40L expression patterns across tissues and their associations with MS, enabling more comprehensive genotype–phenotype analyses. Finally, we relaxed the threshold of p value, which means the correlation between exposure and IVs is relatively small, although the F‐statistics of all IVs are > 10.