PD patients show altered BMAL1 and Neuronal PAS Domain Protein 2 (NPAS2) expression,4 also, altered melatonin secretion patterns and elevated cortisol levels also altered melatonin secretion patterns, and elevated cortisol levels that are linked to sleepiness, sleep architecture changes, and mood disturbances.3, 38, 39. This evidence concerns the gene NPAS2 and Parkinson disease.