FH and infarction: However, a novel FH peptide ‘FHKHKSPALSPV’‐neutrophil membrane proteins (NMPs)‐artificial lipid (Li) membranes‐mesoporous silica nanoparticle (MSN) core (FNLM)‐nanocaged p16INK4a‐siRNA, as a newly constructed nanomaterial drug, could prevent post‐infarction ventricular remodelling through inhibiting NLRP3 transcription in targeted cardiac fibroblasts and ameliorating proinflammation and profibrosis.