Compared with higher‐p16‐expressed people, a significant decrease was shown in the EZH2 and STAT3 double positive areas or cells in lower‐p16‐expressed people, however, a significant increase of EZH2 and STAT3 double positive areas or cells was shown in DCM patients (Figure 5M,N). Here, STAT3 is linked to familial dilated cardiomyopathy.