Compared with higher‐p16‐expressed people, a significant decrease was shown in the p16 and STAT3 double positive areas or cells in lower‐p16‐expressed people, however, a significant increase of p16 and STAT3 double positive areas or cells was shown in DCM patients (Figure 4L,M). This evidence concerns the gene CDKN2A and familial dilated cardiomyopathy.