To elucidate the critical role of p16‐accumulated ageing cardiac fibroblasts in ventricular remodelling following MI, mouse cardiac fibroblasts (MCFBs) were isolated from 8‐week‐old WT, 12‐month‐old p16‐KO and WT mice, labelled with DiI stain, and then transplanted into the infarcted and peripheral areas of 8‐week‐old MI mice (Figure 7A). The gene discussed is CDKN2A; the disease is myocardial infarction.