Carriers of BRCA2 PVs (N = 1629) had a significantly increased risk for four core HBOC‐associated cancers (breast, ovarian, pancreatic, and prostate) and six additional types of cancer (lung, oral, small intestine, larynx, liver, and mesothelioma), hazard ratio (HR) > 2.37, all ps < 0.001. The gene discussed is BRCA2; the disease is cancer.