To assess the accuracy of cancer risk assessment using BRCA2 and cancer‐specific PGS, we developed two Cox regression models (BRCA2‐only and BRCA2 + PGS, both include age, gender, and top 4 PCs) for the two most common HBOC cancers (female breast cancer and prostate cancer) in a randomly selected 50% of the subjects. The gene discussed is BRCA2; the disease is breast cancer.