It has been hypothesized that individuals with 1 or 2 copies of the met allele of the Val66Met polymorphism may show a decreased response to neuroplasticity-based interventions due to diminished BDNF secretion.63 This study is the first to investigate the impact of the Val66Met polymorphism on serum BDNF levels in response to CE in individuals with stroke. This evidence concerns the gene BDNF and Stroke.