Our findings align with other studies in neurotypical individuals reporting inconclusive results on the association between this genetic variant and BDNF levels following CE interventions,31,65,66 as well as its impact on post-stroke recovery outcomes.67,68 Nevertheless, these findings should be interpreted with much caution due to the larger sample sizes typically required to detect true effects in genetic studies,69 and the inherent variability of the BDNF response to exercise29 as well as of clinical stroke research.70 This evidence concerns the gene BDNF and stroke disorder.