BDNF and stroke disorder: This disparity between BDNF sources has also been observed during early post-stroke stages in animal models, where BDNF concentrations increase in the brain, while no changes are reported peripherally.60 This discrepancy underscores the need for caution in interpreting human studies and highlights the necessity for further studies to elucidate the role of circulating BDNF in central neural processes and its association with stroke recovery.