The top 10 pathways are cytokine-receptor interaction (hsa04060), ECM-receptor interaction (hsa04512), RA (hsa05323) and chemokine signaling pathway (hsa04062), focal adhesion (hsa04510), cytosolic DNA-sensing pathway (hsa04623), apelin signaling pathway (hsa04371), viral protein interaction with cytokine and cytokine receptors (hsa04061), and viral myocarditis (hsa05416) and insulin resistance (hsa04931) (Fig. 3D). This evidence concerns the gene APLN and Insulin resistance.