The mRNA expression of α-SMA and collagen I, which are the most commonly used as indicators for HSC activation have been reported in the literature [24–26], and the area of egg granuloma in the mouse liver peaked at 6 weeks after infection and then decreased at 9 and 12 weeks, while the protein expression of α-SMA, collagen I, and the fibrosis area peaked at 9 weeks after infection of the late stage, which was consistent with previous reports [27–29]. The gene discussed is ACTA1; the disease is infection.