PTPRC and Splenomegaly: The shPSMB10 THP-1 cells + T cells co-transplant group, related to control groups, had markedly prolonged survival in the 1st transplantation NCG mice (shPSMB10 + T cells: 58 days vs shCTRL cells: 38 days, p < 0.0001; Fig. 3B) and a lower percentage of human CD45+ (hCD45+) leukemia cells in the peripheral blood (PB), BM, and spleen and less severe splenomegaly (Fig. 3C-E) when the mice were sacrificed at 5 weeks.