CD34 and acute myeloid leukemia: After employing siRNA to reduce PSMB10 expression in primary CD34+ BM cells (FAB, M0/M1/M2) and BM mononuclear cells (FAB, M5) isolated from AML patients, we found that PSMB10 downregulation similarly increased the intracellular DNR concentration in these primary AML cells (Fig. 4E).