After employing siRNA to reduce PSMB10 expression in primary CD34+ BM cells (FAB, M0/M1/M2) and BM mononuclear cells (FAB, M5) isolated from AML patients, we found that PSMB10 downregulation similarly increased the intracellular DNR concentration in these primary AML cells (Fig. 4E). Here, PSMB10 is linked to acute myeloid leukemia.