As we used AraC to induce leukemia senescence, we discovered that the downregulation of PSMB10 increased SA-β-Gal activity (Fig. 4B), the proportion of cells in G0/G1 phase (Fig. 4C and D) and SASP factor levels, and decreased cell cycle-associated gene expression (Supplementary Fig. S3A) in different AML cell lines. The gene discussed is PSMB10; the disease is acute myeloid leukemia.