RPS6 and leukemia: Here, we uncovered previously unknown mechanisms by which the downregulation of RPs expression in leukemia cells enhances the translation of MDM2 via increased RPL6-mediated translation efficacy and RPS6-mediated translation initiation, and simultaneously leads to a decreased direct bind to MDM2 protein in the complex form of both RPL6 and RPS6 proteins, which further promotes the MDM2-mediated ubiquitin-independent degradation of P21 protein.